What is Sebela Pharmaceuticals Inc. Analpram HC Cream 2.5%?

Analpram HC is advertised to deal with the inflammation and itching of the anal area caused by certain skin disorders. It is a combination of topical corticosteroid and Pramoxine.  Hydrocortisone works by reducing skin irritations, such as swelling and itching. Pramoxine works by stopping nerves from sending pain signals to the brain. Together, they help to improve your condition.


The primary formulation of Analpram HC Cream includes:

  • Hydrocortisone acetate 2.5 %
  • Pramoxine hydrochloride 1%

The other ingredients are stearic acid, cetyl alcohol, Aquaphor, isopropyl palmitate, polyoxyl 40 stearate, propylene glycol, potassium sorbate, sorbic acid, triethanolamine lauryl sulfate, and purified water.


It is strongly recommended to use this product around the rectal area only. Before use, clean the affected area with mild soap and warm water. Rinse well, and pat it dry. Apply a small amount of Analpram HC Cream to the affected area and rub in gently. Repeat this procedure 3 to 4 times daily depending on the severity of the condition or as directed by your doctor.

It is advised to wash your hands before and after the use of this product. Avoid getting the product in your eyes, nose and ears. Do not keep using this product longer than prescribed by your doctor. Tightly covering the affected area after using this product may increase the risk of side effects.


Each supply of 30 grams will cost around $39. Prices may vary depending on the pharmacy you visit. This price is specifically for the customers paying cash and not valid for customers with insurance plans. We could not find any manufacturer promotions for this product. 

Possible Side Effects

There are numerous side effects stated by the manufacturer on the official website. Although these side effects are infrequently reported during the use of this product, they may occur more frequently if customers use a tight dressing over their hemorrhoids.

Following are the possible side effects of Analpram HC Cream:

  • Burning
  • Itching
  • Irritation
  • Dryness
  • Folliculitis
  • Hypertrichosis
  • Acneiform eruptions
  • Hypopigmentation
  • Perioral dermatitis
  • Allergic contact dermatitis
  • Maceration of the skin
  • Secondary infection
  • Skin atrophy
  • Striae
  • Miliaria

Those who are allergic to any of the ingredients in this product should not use it.

Manufacturers Commitment

We were unable to find any guarantees offered by the manufacturer, and since you will have to pick your distributor or store, you should factor in their customer policies. On average, customer reviews are positive. However, there were a few clients who were not satisfied with the effectiveness of this product.

The Bottom Line

Analpram HC could be helpful for people with rectal inflammation and itching. Directions to use the product are straightforward and easy to follow. However, the list of possible side effects is very long. Customers should always consult a physician in any scenario. Overall customer reviews are good with a few unhappy customers complaining about the effectiveness of Analpram HC Cream.

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